Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China

Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China

Blog Article

The transmission of Unique Recombinant Forms (URFs) has complicated the molecular epidemic of HIV-1.This increasing genetic diversity has implications for prevention surveillance, diagnosis, and vaccine design.In this study, we characterized the HIV-1 URFs from 135 newly diagnosed HIV-1 infected cases between 2016 and 2020 in Shenyang, northeast China and analyzed the evolutionary relationship of them by phylogenetic and Latest Product Releases & Innovations – Stay Updated! recombination approaches.Among 135 URFs, we found that the CRF01_AE/CRF07_BC recombinants were the most common (81.5%, 110/135), followed by CRF01_AE/B (11.

9%, 16/135), B/C (3.7%, 5/135), and others (3.0%, 4/135).94.8% (128/135) of patients infected by URFs were through homosexual contact.

Among 110 URFs_0107, 60 (54.5%) formed 11 subclusters (branch support value = 1) and shared the consistent recombination structure, respectively.Four subclusters have caused small-scale spread among different high-risk here populations.Although the recombination structures of URFs_0107 are various, the hotspots of recombinants gathered between position 2,508 and 2,627 (relative to the HXB2 position).Moreover, the CRF07_BC and CRF01AE fragments of URFs_0107 were mainly derived from the MSM population.

In brief, our results reveal the complex recombinant modes and the high transmission risk of URFs_0107, which calls for more attention on the new URFs_0107 monitoring and strict control in the areas led by homosexual transmission route.